Endocrine Abstracts

We report a case of a 25 years old woman – with central transient hypoadrenalism after the right adrenalectomy for Cushing syndrome. She became pregnant 1 year after surgery while still taking a small dose of cortisol replacement therapy (5 mg Hydrocortisone) for partial recovery of her corticotrophic axis. Her pregnancy has been complicated by gestational diabetes, with good metabolic control under small doses of basal insulin. She increased her substitutive therapy at 2...

Introduction: The female genital developmental defects are not common in non-classical congenital adrenal hyperplasia (CAH). The causes of amenorrhea are multifactorial and are due to the incomplete control of hyperandrogenism as well as the increased progesterone, acting in various modes: blunted LH mid-cycle surge, lack of progestin withdrawal action and antagonise the estradiol action on the endometrium. The overtreatment with glucocorticoid results in the suppression of go...

N-terminal peptide of type I procollagen (P1NP) is a marker of GH (hGH) anabolic action on bone formation. We evaluated the diagnostic value of P1NP in GH deficiency (GHD) in the transition period using receiver operating characteristic (ROC) plot analysis. We compared the diagnostic value of P1NP with IGF1. 16 male patients (chronological age, 16.6–21.5) with GH replacement therapy during childhood (ten IGHD and six MPHD) were evaluated at minimum 3 months after completi...